Growth Hormone Deficiency and Metabolism

Hypopituitarism and Weight Loss with Growth Hormone Deficiency.

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I was asked to write some blogs on Nutrition, our Hormones and how we can find ways to better our health.  There is so much to write on the effects of Hypopituitarism that I am going to break these down by each hormone and work our way through them starting with Growth Hormone.  In my next blog I will address the next deficiency.

Before you read this and follow what I am doing, I always like to say that I am not a doctor and I am only writing on the things I have learned from my endocrinologist, nutritionists and hours of investigating online.  These are things that have worked for me.  Please remember these things may not work for everyone.  This is all based on science that you can look up yourself in reputable journals and medical studies.

Growth hormone is a major body system-wide metabolic hormone that regulates carbohydrate homeostasis (balance), protein and lipids (fat). Carbs, Proteins, and Fats!

Carbohydrates

Patients with growth hormone deficiency have traditionally been described as having increased insulin sensitivity (resistance).  Being Hypopituitary is close to what’s called having Metabolic Syndrome although ours is hormone related. Insulin Resistance has been studied and proven numerous times.  They have also shown that long-term treatment in GH-deficient adults results in persistent insulin resistance and abnormalities in how we process Insulin…even when on Somatropin.

Insulin is a hormone, just like estrogen, testosterone, cortisol and thyroid hormone. Insulin is secreted into our bloodstream by the pancreas to regulate the amount of glucose in our blood. Insulin allows our body to use sugar (glucose) from carbohydrates in the food that you eat for energy or to store glucose for future use.  Insulin is often described as a “key,” which unlocks the cells to allow sugar to enter the cell and be used for energy.  Insulin acts on many cells in your body, especially those in the liver, muscle and fat tissue. Insulin tells the cells to do the following:

  • Absorb glucose, fatty acids and amino acids
  • Stop breaking down glucose, fatty acids and amino acids; glycogen into glucose; fats into fatty acids and glycerol; and proteins into amino acids
  • Start building glycogen from glucose; fats (triglycerides) from glycerol and fatty acids; and proteins from amino acids

Blood sugar is like a vampire. It needs an invitation to enter our cells. And that invitation is insulin. Insulin is the key that unlocks the door to let the glucose in the blood to enter the muscle cell. When we have insulin resistance, we no longer have the ability to respond to insulin. Normal amounts of insulin are no longer adequate to produce a normal insulin response from fat, muscle and liver cells. In order to compensate, the pancreas produces more insulin. Insulin resistant cells cannot take in glucose, amino acids and fatty acids. Thus, glucose, fatty acids and amino acids ‘leak’ out of the cells. Exess glucose is converted into Glycogen. This then causes fat cells to absorb fatty acids and glycogen and thus expand.

The higher the insulin, the more the fat cells have to expand.  If you have insulin resistance and eat carbohydrates, up to five times the amount of insulin is necessary to bring your blood glucose back down to healthy levels. And some people with insulin resistance produce so much insulin that their blood sugar levels can drop way below normal, forcing us into a hypoglycemic state. When we experience intense cravings for sugary or starchy foods, there’s a good chance it’s due to hypoglycemia. I also believe that because we are not absorbing the glucose into our cells this is causing our lack of fuel for our energy levels.  We also need the glucose in the cells for our brains to function.

When insulin levels spike due to high glucose levels, it creates fat. And the more obese you are, the more insulin resistant you become.  Now the second issue comes into play for us that are Hypopituitary is that Cortisol which would normally be secreted from the adrenal gland is supposed to make fat and muscle cells resistant to the action of insulin.  Cortisol is also supposed to enhance the production of glucose by the liver. Under normal circumstances, cortisol counterbalances the action of insulin. Under stress or if a synthetic cortisol is given as a medication (like many of us), our cortisol gets used up quicker and we remain insulin resistant.  Low cortisol, low blood sugar equals hypoglycemia and possibly Adrenal Crisis.  Sounds like so much fun doesn’t it.  Cortisol and its effects on metabolism I will get into in my next blog.

Most people with insulin resistance don’t know they have it for many years—until they develop type 2 diabetes, a serious, lifelong disease. The good news is that if we find out we are borderline with high triglycerides, higher than normal blood glucose, abnormal (low) levels of good Cholesterol in our blood tests we can address insulin resistance early on.  We can often prevent or delay diabetes by making changes to our lifestyle.

What causes this insulin spike?  Sugars!  When people eat a food containing sugar, the digestive system breaks it down at which point it enters the blood.  Blood glucose levels then shoot up, and our pancreas creates the insulin as mentioned above.  Also Carbohydrates. When people eat a food containing carbohydrates, the digestive system breaks down the digestible ones into sugar, which enters the blood.  Repeat above.

In the past, carbohydrates were commonly classified as being either “simple” or “complex”. However, this does not account for the effect of carbohydrates on blood sugar and chronic diseases. To explain how different kinds of carbohydrate-rich foods directly affect blood sugar, the glycemic index was developed and is considered a better way of categorizing carbohydrates, especially starchy foods.  The University of Sydney has a great searchable index that can be found here http://www.glycemicindex.com/.  Low-glycemic foods have a rating of 55 or less, and foods rated 70-100 are considered high-glycemic foods. Medium-level foods have a glycemic index of 56-69.

Proteins

One of the other issues with Growth Hormone deficiency is that our Protein synthesis and flux are reduced. Growth hormone is the only hormone to exert its function directly to our cells. Growth hormone increases the rate of protein synthesis within cells by increasing the transport rate of Amino Acids into the cells similar to the method insulin uses.  Replacement GH increases synthesis initially but it’s not sustained long term like we require.  It is also proven that Insulin resistant cells do not uptake amino acids well as mentioned above.

During digestion the proteins we eat are broken down and converted into Amino Acids for our cells.  Twenty percent of the human body is made up of protein. Protein plays a crucial role in almost all biological processes and amino acids are the building blocks of it.

A large proportion of our cells, muscles and tissue is made up of amino acids, meaning they carry out many important bodily functions, such as giving cells their structure. They also play a key role in the transport and the storage of nutrients. Amino acids have an influence on the function of organs, glands, tendons and arteries. They are furthermore essential for healing wounds and repairing tissue, especially in the muscles, bones, skin and hair as well as for the removal of all kinds of waste deposits produced in connection with the metabolism.

Adults produce 9 of the 22 essential amino acids and the remainder come from food. Failure to obtain enough of even 1 of the 9 essential amino acids, those that we cannot make, results in degradation of the body’s proteins (muscle and so forth) to obtain the one amino acid that is needed. Unlike fat and starch, the human body does not store excess amino acids for later use.  Amino acids must be in the food we eat every day.

There are 9 essential amino acids which humans must obtain from their diet in order to prevent protein-energy malnutrition. They are:

  • Phenylalanine
  • Valine
  • Threonine
  • Tryptophan
  • Methionine
  • Leucine
  • Isoleucine
  • Lysine
  • Histidine

Increasing your protein intake and adding quality Amino Acid supplements is a good idea to help us get enough. It’s easy to add protein to your diet with Whey Protein shakes available in most stores.  Just watch for sugar content as they are not created equal.  I use a product from Precision Supplements up here in Canada and I get paid nothing for endorsing their chocolate!  YUM! I am sure there is another brands where you live.

Fats (Lipids)

Growth hormone promotes the use of lipids by promoting the breakdown of triglycerides and oxidation in cells. When people eat less fat, they tend to eat more starch or sugar instead, and this actually increases their levels of dangerous cholesterol, the small, dense cholesterol that causes heart attacks. In fact, studies show that 75% of people who end up in the emergency room with a heart attack have normal overall cholesterol levels.  What they do have is pre-diabetes or type 2 diabetes.

Eating a diet with good quality fat and protein prevents and even can possibly reverse diabetes and pre-diabetes.  Eating sugar and refined carbs is the primary cause of these conditions.  Healthy Fats do not increase insulin.  Dietary fat cannot be converted to blood sugar, and therefore it doesn’t cause serum insulin levels to increase.

It might seem counterintuitive to eat fat if you’re trying to lose weight and use stored fat for energy, but dietary fat does not induce the high levels of insulin secretion seen with a very high-carb meal. Therefore, when the body is relying less on glucose and more on fat for energy, insulin secretion is decreased.  Ultimately, this allows the body to continue efficiently accessing fat stores for energy.

 

Ok now that the science lesson is over, what do we do about it?  If you are like myself and working towards losing weight, we need to reduce our consumption of sugars and carbohydrates and increase fats and Proteins.  It sounds simple and truly it is.  But you have to be committed to it if you are hypopituitary.  Or at least, give it 30 days and see what happens.  30 days.  That’s all I ask.  See if you feel different.

There are many eating plans you can find online in regards to a Ketogentic way of eating and I highly recommend some of them.  The main benefit of ketosis is that it increases the body’s ability to utilize fats for fuel. Our bodies get very lazy on a high-carbohydrate diet. When on high-carbohydrate diets, the body can usually expect an energy source to keep entering the body. But in the state of ketosis, the body has to become efficient at mobilizing fats as energy.

I don’t follow the Low Carb, High Fat mentality of some keto dieters as I don’t believe it’s a long term plan for us due to other hormone and nutrient deficiencies…which I will explain in a future blog.  I do recommend the Moderate Fat, Moderate Protein, Low Carb way of eating. For fat loss (not muscle loss) we need to keep our fats a bit lower or equal to our proteins per day.  There is a warning I will give.  If you decide to give this a try you may experience what is called the keto flu.  What’s happening is your body transitioning from carb burning to fat burning.  It’s a rough ride and I did have to stress dose my cortisol a few times to make it through some days.  But once through it, you will notice a tremendous difference.  You will want to keep your electrolytes up always.  I also supplemented with Salt, Magnesium and Potassium while on this way of eating mostly through a One a Day Vitamin.

If you can, pickup a book called “The Art and Science of Low Carbohydrate Living” by Doctors Volek and Phinney.  They also have many videos on Youtube and blogs everywhere. Their website is http://www.artandscienceoflowcarb.com/.  There is also a great Facebook group you can join called Ketogenic Dieters.  There are others but I highly recommend this one.  To track my eating and ensure I keep my carbs, proteins and fats where I want them to be, I use My Fitness Pal which is an app or can be used on your computer also.  There is also a list of conditions where you should not try the Keto way of eating.  It can be found here http://www.ketogenic-diet-resource.com/support-files/who-should-not-follow-a-ketogenic-diet.pdf.

Lastly in regarding to nutrients I would like to add that if you are GH deficient you need to be on a quality Vitamin D3.  Even if your levels are normal this will help you.  Vitamin D3 is one of the most useful nutritional tools we have at our disposal for improving our overall health. This vitamin is unique because as a hormone, Calcitriol controls phosphorus, calcium, and bone metabolism and neuromuscular function. Vitamin D3 is the only vitamin the body can manufacture from sunlight. Yet, with today’s indoor living and the extensive use of sunscreens due to concern about skin cancer, we are now mostly deficient.

For more than a century, scientists have recognized that Vitamin D3 is involved in bone health. Research has continued to accumulate, documenting Calcitriol’s role in the reduction of the risk of fractures to a significant degree. The latest research, however, shows that Vitamin D3 deficiency is linked to a surprising number of other health conditions such as depression, back pain, cancer, “insulin resistance”, pre-eclampsia during pregnancy, impaired immunity and macular degeneration.  I recommend 5000 to 8000 IU per day.

I am certainly not saying in any way this is a cure for Hypopituitarism, or replaces the hormones we all need daily.  I have tried Keto myself and lost 25 lbs over three months. I felt stronger and began exercising which helped with my mental attitude and abilities.  I have proven to myself that eating like this is something I could maintain long term.  And I also have proven to myself that when I fall off of this ways of eating and go back to carbs, the weight climbs, I feel less energetic and the brain fog moves in fairly quickly.

Don’t kick yourself for falling off the wagon.  We all do it.  Just choose to climb back on as soon as possible.  We have enough other challenges to deal with daily with our hormones that although weight loss is important for our health, happiness is the most important.  Once you start to feel better hopefully you can start moving again and burn those extra fat cells off even quicker through some exercise.

The fact is, lowering insulin levels will may help you lose weight and make you thinner.  This is my recommendation and I always suggest you do your own research and discuss this with your physician before trying any nutrition and exercise routine.  However, remember too that most classically trained doctors don’t understand the effect of foods on the body, much less ketogenic diets, so if you ask your physician, you may get push back, and a terrifying “danger of ketosis” sermon.  Just remember the doctor is confusing nutritional ketosis with a more dangerous condition called ketoacidosis. These are two different conditions.  Ketoacidosis is a concern for Type 1 diabetics and others whose bodies are unable to make or process insulin correctly.  Educate yourself and be prepared like we have to do with our Hypopituitarism.

I hope this helps someone.  Please feel free to comment as I am always learning myself.  Take care all and live well!

Author: kmuir2723

My journey started in February of 2008 when I was rushed to emergency with blinding pain in my head. I was taken by ambulance to have a CT scan and when it came back negative I was misdiagnosed with Ice Pick Migraines. Over the years I would return to emergency a few more times for the same issue and they would just treat it as a migraine because that is what they treated it as before. Since then my body and personality has been through many changes and many more misdiagnosis. From carpel tunnel, computer elbows, rheumatoid arthritis, Gluten Intolerance and erectile dysfunction just to name a few. My memory and concentration levels were getting fading. I had little to no energy most of the time and I was losing interest in things I used to enjoy. My social skills diminished and I struggled to be around groups of people without anxiety. When I could no longer function properly sexually I convinced my doctor to run more tests. The results showed an extremely low testosterone level. I thought to myself, no big issue, they make medication for that but my doctor chose to send me to an endocrinologist to find out why. In August of 2013 I met with my endocrinologist and after numerous tests a 4 cm Macroadenoma (pituitary tumor) was discovered. The tumor was putting pressure on my Pituitary gland which in essence shut down most of the hormones in my body. I no longer had a functional adrenal system. We will never know how long the tumor was growing but the neurosurgeon estimates up to 20 years. The MRI showed evidence of scare tissue formation on the tumor from previous hemorrhages over the years. Upon review of the 2008 CT scan he pointed out the quarter size tumor that was missed. The migraines I was having was actually pituitary apoplexy or hemorrhages. I was very lucky to be alive. The surgeon informed me they lost a patient on the table the day before for the same apoplexy. My tumor was removed transsphenoidally on Oct 7th. 2013. They could only remove about 80% of it because of the proximity to the carotid arteries and optic nerves. There is a high probability it will grow back and if so, Radiation therapy is our next weapon against it. My hormones may never return to being created naturally so I am on medications for Cortisol (Adrenal system), Thyroxine (Thyroid Gland), Testosterone, (Sex Glands) and Somatropin (Growth Hormone) eventually. Since my surgery I have become separated after 23 years. It was hard but this thing changed me as a person and I cant go back to who I was before, even if I could remember who that was. I also lost my best friend of 30 years to a brain Tumor in February. He was there for me during my rough time this year and I will miss him deeply. My goal now is to help others going through this challenge and help to educate people to fight our medical system for their health. Never assume no news is good news when you don't get results of test back from your doctor. Be your own advocate. My fight continues but every day is a blessing and I chose to live it happy.

8 thoughts on “Growth Hormone Deficiency and Metabolism”

  1. This is an upcoming video conference on insulin & diet that may be interesting as a follow up to this post. I am primarily vegetarian, eat healthy carbohydrates, am panhypopituitary and my BMI & weight are normal. I am opposed to a ketogenic diet or eating high protein, Read The China Study by T. Colon Campbell, Ph.D, or a new book Proteinoholic. Anyone can sign up for this videoconference: Dr. Friedman, an Endocrinologist in Los Angeles (goodhormonehealth.com) and Dr. Dae, a Naturopath in Washington DC (healthydaes.com) will be teaming together to host a videoconference on “Eating Well to Reverse and Prevent Diabetes, Hormone Imbalances, Fatigue and Obesity” on Sunday January 10, 2016 at 6 PM PST/9 PM EST. Please RSVP to mail@goodhormonehealth.com by January 6th with the subject header “Eating Well”. We will then send out an invitation (from AXIS concierge) giving you log in information to join on a website (that will allow you to hear the presentation and view the slides) or by telephone (that will allow you only to hear the presentation). There will be time for questions by “chat” and the videoconference will be posted on goodhormonehealth.com and healthydaes.com a few days after. You will be required to mute your phones/computers. Please contact us at mail@goodhormonehealth.com or DrDae@Healthydaes.com.if you have questions.

    1. Everyone is entitled to thier own opinion and I am not opposed to any way of eating that is healthy and works for you. I am suprised anyone would be opposed to a scientifically proven way of eating. As I mentioned, I am relating information from my investigations, my pituitary specialist, and nutritionist that have worked for me. If you are happy with your way of eating then that works for you. For many people they need options to find what can work for them.

  2. My problem is that my body isn’t producing the digestive fluids necessary for me to process most foods. Can’t eat insoluble fiber, only small amounts of soluble fiber if it’s cooked to mush, and meat must be ground. One of my endos at Stanford said the pituitary gland is responsible for producing digestive fluids, so I’ve been on a bland, soft diet for 15 yrs. They only found the adenoma just over a year ago and I’ve started injections of Somatropin recently, but it will be 6-12 months before we know if it helps or not. My pituitary was compressed when my brain swelled following a head injury 39 yrs ago, and they say they’ve never had a patient my age with this issue (or who’d suffered from it for so long) because few survived such severe head trauma in ’78. My dad was a doctor so I was raised on the healthiest diet you can imagine, and I’d love to eat like a normal person again! If anyone else has had a similar experience, I’d love to hear what you have to say. Thanks.

    1. Do you have pancreatic insufficiency? All of the people I talk to regularly with non functioning pituitary glands like myself and I have never heard of the pituitary releasing something that for producing digestive fluid. I will have to look into that.

  3. Hello, I think i have this same issue. I have 0 libido, lost interest in many thing. Tired all the time. Looks like I have low GH. Is there anywhere I can contact you directly? Thanks

  4. Thank you for the great post!

    I am suffering from hypothyroidism since long time, however I have discovered recently that I have a great deficiency in hGH. I am in 1 iu every other day. My IGF1 jumped from 180 into 227. Still I am feeling fatigued.

    I am trying to follow low carb diet, howver it feels so hard due to strong brain fog. On my fitness pal , any thing under 120g carbs will make me suffer big time. PROTEIN is 100g and fat is 60.

    Please advise what would be the diet, and the workout look like. The stamina is low, and the main complain isnbeing fatigued all the time.

    Appreciate your help and all the best!

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